A new series of substituted benzimidazole derivatives were synthesized based by N-Mannich reaction. Compound B1-B22 synthesized from benzimidazole and 2-mercapto benzimidazole by reacted with formaldehyde and appropriate amine like 5-amino tetrazole, 2-amino pyrazine, Morpholine, Piperidine, aniline, 4-fluro aniline, 4-amino benzoic acid, Isoniazid, diphenylamine, Trietylamine in ethanol. New 22 compounds synthesized based upon Mannich base reaction from the review of literature and characterized by their physical and spectral (IR, PMR and Mass) data. All the compounds have been screened for antituberculosis activities by most of these compounds have shown promising antituberculosis activity.\
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